Smyth Lab

Journal Publications

• Sherbiny, I., Smyth, H. Novel Cryomilled Physically Crosslinked Biodegradable Hydrogel Microparticles as Carriers for Inhalation Therapy, Journal of Microencapsulation, ACCEPTED
• Sherbiny, I., McGill, S., Smyth, H., Swellable Microparticles as Carriers for Sustained Pulmonary Drug Delivery, Journal of Pharmaceutical Sciences, ACCEPTED PMID:19967777
• Hunter, Z., Smyth, HDC, Durfee, P. Chackerian, B., Induction of mucosal and systemic antibody responses by aerosol delivery and intramuscular immunization of Virus-like Particle based vaccines targeting CCR5, Vaccine, Accepted
• McGill, Shayna L; Cuylear, Carla L; Adolphi, Natalie L; Osinski, Marek; Smyth, Hugh D C. 2009. Magnetically responsive nanoparticles for drug delivery applications using low magnetic field strengths. IEEE Trans Nanobioscience 8 (1):33-42. DOI:10.1109/TNB.2009.2017292
• McGill, S.L., Cuylear, C.L., Adolphi, N.L., Osin'ski, M., Smyth, H.D.C., Enhanced drug transport through alginate biofims using magnetic nanoparticles., Proceedings of SPIE, Volume 7189, pp. 18-7 -18-8 (2009)
• Donovan, M., Selvam, P., Singh, S., McNair, D., Truman, R., Smyth, H.D.C., Tunable Dry Powder Inhalers: Future or Folly, Invited Review, Respiratory Drug Delivery, Vol 1, pp 189-200, 2009.
• Smyth, HDC; Becket, G; Mehta, S. 2009. The influence of porosity changes in human epidermal membrane during iontophoresis on the permeability enhancement of a model peptide. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 35 (10):1201-1209. DOI:10.1080/03639040902865673
• Saleem, I; Smyth, H; Telko, M. 2008. Prediction of dry powder inhaler formulation performance from surface energetics and blending dynamics. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 34 (9):1002-1010. DOI:10.1080/03639040802154905
• Hunter, Zoe; Smyth, Hugh D; Durfee, Paul; Chackerian, Bryce. 2009. Induction of mucosal and systemic antibody responses against the HIV coreceptor CCR5 upon intramuscular immunization and aerosol delivery of a virus-like particle based vaccine.. Vaccine 28 (2):403-14. DOI:10.1016/j.vaccine.2009.10.035
• Hickey, AJ; Mansour, HM; Telko, MJ; Xu, Z; Smyth, HDC; Mulder, T; McLean, R; Langridge, J; Papadopoulos, D. 2007. Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics. JOURNAL OF PHARMACEUTICAL SCIENCES 96 (5):1282-1301. DOI:10.1002/jps.20916
• Hickey, AJ; Mansour, HM; Telko, MJ; Xu, Z; Smyth, HDC; Mulder, T; McLean, R; Langridge, J; Papadopoulos, D. 2007. Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics. JOURNAL OF PHARMACEUTICAL SCIENCES 96 (5):1302-1319. DOI:10.1002/jps.20943
• Saleem, I., Donovan, M. J., Smyth, H. D. C., Particle size analysis: from microparticles to nanosystems, American Pharmaceutical Review, 2007, 10(2) p 126-130.
• Smyth, H. D. C., Brace, G., Barbour, T., Grove J., Gallion, J., Hickey, A.J., Spray pattern analysis for metered dose inhalers I: orifice size, particle size, and droplet motion correlations. Drug Development and Industrial Pharmacy, 2006, 32(9) 1033-1041. DOI:10.1080/03639040600637598
• Smyth, H; Brace, G; Barbour, T; Gallion, J; Grove, J; Hickey, AJ. 2006. Spray pattern analysis for metered dose inhalers: Effect of actuator design. PHARMACEUTICAL RESEARCH 23 (7):1591-1596. DOI:10.1007/s11095-006-0280-z
• Smyth, H.D.C., Brace G., Barbour T., Gallion J., Grove J., Hickey AJ., "Actuator Design Variables For Particle Size Modulation" in Respiratory Drug Delivery X, Editors: Richard N. Dalby, Peter R. Byron, Joanne Peart and Julie Suman, 2006, 857-860.
• Smyth, H.D.C., Brace G., Barbour T., Gallion J., Grove J., Hickey AJ., "Influence of Actuator Design on Spray Pattern Analysis of Metered Dose Inhalers" in Respiratory Drug Delivery X, Editors: Richard N. Dalby, Peter R. Byron, Joanne Peart and Julie Suman, 2006. 861-864.
• Smyth, HDC; Leach, CL. 2005. Alternative propellant aerosol delivery systems. CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS 22 (6):493-534.
• Martonen, Ted B; Smyth, Hugh D; Isaacs, Kristin K; Burton, Ray T. 2005. Issues in drug delivery: concepts and practice.. Respir Care 50 (9):1228-52. PMID:16163810
• Smyth, H.D.C., Hickey, A.J., "Carriers in Drug Powder Delivery: Implications for Inhalation System Design": American Journal of Drug Delivery, vol. 3, no. 2, pp. 117-132, 2005. DOI:10.2165/00137696-200503020-00004
• Smyth, H. D. C. Propellant driven metered dose inhalers for pulmonary drug delivery, Expert Opinion on Drug Delivery. 2(1), pp. 53 - 74, 2005 DOI:10.1517/17425247.2.1.53
• Smyth, H.D.C., Garcia-Contreras, L., Dry-Powder and Liquid Spray Systems for Inhaled Delivery of Peptides and Proteins, American Journal of Drug Delivery, vol. 3, no. 1, pp. 29-45(17) 2005.
• Smyth, Hugh D C; Beck, Vance P; Williams, Dennis; Hickey, Anthony J. 2004. The influence of formulation and spacer device on the in vitro performance of solution chlorofluorocarbon-free propellant-driven metered dose inhalers. AAPS PharmSciTech 5 (1):E7.
• Smyth, H.D.C., Cooney D.J., Garmise R.J., Zimmerer, R.O., Pipkin, J.D., Hickey A.J. Dynamic Electrostatic Charge Determinations of Dry Powder Blends for Inhalation: Correlations with dispersion performance Influence of Physical Form of Captisol®, Respiratory Drug Delivery IX Volume III, Editors: Richard N. Dalby, Peter R. Byron, Joanne Peart and Stephen J. Farr, p805-807. 2004.
• Smyth, H.D.C., Garmise R.J., Cooney D.J., Zimmerer, R.O., Pipkin, J.D., Hickey A.J. Influence of Physical Form of Captisol® Particles on Performance as A Dry Powder Aerosol Carrier, Respiratory Drug Delivery IX Volume III, Editors: Richard N. Dalby, Peter R. Byron, Joanne Peart and Stephen J. Farr, p809-811. 2004.
• Garcia-Contreras L., Cooney D.J., Smyth, H.D.C., Zimmerer, R.O., Pipkin, J.D., Hickey A.J. Evaluation of cyclodextrin-rifampicin solutions in CALU-3 monolayer cell culture system, Respiratory Drug Delivery IX Volume III, Editors: Richard N. Dalby, Peter R. Byron, Joanne Peart and Stephen J. Farr, p797-799, 2004.
• Smyth, H.D.C., Factors Influencing Particle Size Analysis of Micronized Powders, American Pharmaceutical Review, Fall issue, Pages 100-104, 2003.
• Smyth, Hugh D C; Hickey, Anthony J. 2003. Multimodal particle size distributions emitted from HFA-134a solution pressurized metered-dose inhalers.. AAPS PharmSciTech 4 (3):E38.
• Smyth, HDC. 2003. The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers. ADVANCED DRUG DELIVERY REVIEWS 55 (7):807-828. DOI:10.1016/S0169-409X(03)00079-6
• Smyth, HDC; Becket, C; Mehta, S. 2002. Effect of permeation enhancer pretreatment on the iontophoresis of luteinizing hormone releasing hormone (LHRH) through human epidermal membrane (HEM). JOURNAL OF PHARMACEUTICAL SCIENCES 91 (5):1296-1307. DOI:10.1002/jps.10132
• Smyth, H.D.C., Hickey A.J., Dynamic Particle Size Distributions Emitted from pMDIs as Determined by Laser Diffraction: A Function of Time and Space, Respiratory Drug Delivery VIII Volume II, Editors: Richard N. Dalby, Peter R. Byron, Joanne Peart and Stephen J. Farr. p727 – 730, 2002.
• Smyth, H.D.C., Hickey A.J., Comparative Particle Size Analysis of Solution Propellant Driven Metered Dose Inhalers Using Cascade Impaction and Laser Diffraction, Respiratory Drug Delivery VIII Volume II, Editors: Richard N. Dalby, Peter R. Byron, Joanne Peart and Stephen J. Farr. p731 – 734, 2002.
• Smyth, H.D.C., Mejia-Millan, E.A., Hickey A.J., The Effect of Ethanol on Solvency, Vapor Pressure, and Emitted Droplet Size of Solution Metered Dose Inhalers Containing HFA 134a, Respiratory Drug Delivery VIII Volume II, Editors: Richard N. Dalby, Peter R. Byron, Joanne Peart and Stephen J. Farr. p735 – 738, 2002.
• Crowder, T.M., Louey, M.D., Sethuraman, V.V., Smyth, H.D.C., Hickey, A.J., 2001: An Odyssey in Inhaler Formulations and Design, Pharmaceutical Technology, 25(7), 99-113, 2001.
• Smyth, H.D.C., Investigation into the mechanism of action and chemical enhancement of transdermal iontophoresis of LHRH, Ph.D.Thesis, University of Otago, New Zealand, 2000.
• Smyth, H.D.C., Mehta, S.C., Becket, G., The Relationship Between Electroosmotic Flow And Electrical Potential Difference In The Human Epidermal Membrane. Perspectives In Percutaneous Penetration, Volume 7b (Eds. K.R. Brain and K.A. Walters) 2000.

Books and Book Chapters

• Smyth, H., Hickey, A.J., Editors: "Controlled Release Science and Technology: Pulmonary Drug Delivery" Controlled Release Society, In Preparation.
• Hickey, A.J., and Smyth, H.D.C., "Pharmaco-complexity: Non-Linear Phenomena and Drug Product Development" Springer, In preparation
• McGill, S., Smyth, H.D.C., "Aerosol Delivery of Nanoparticles", in Pharmaceutical Aerosol Drug Delivery in the 21st Century, M. Hindle, Ed., John Wiley and Sons, In preparation
• Marek, S.R., Smyth, H.D.C., Garmise, R., Garcia-Contreras, L., Hickey, A.J. Medical and Pharmaceutical Aerosols in Aerosols Handbook: Measurement, Dosimetry, and Health Effects, 2nd Edition, Ruzer, L. & Harley, N.H. (eds), CRC Press. In preparation
• Smyth, H. D. C., Saleem, I., Donovan, M. J., Verschraegen, C. F., Pulmonary Delivery of Anti-Cancer Agents, in Advanced Formulation Design to Optimize Therapeutic Outcomes, Drugs and the Pharmaceutical Sciences, Vol 172, RO. Williams , DR. Taft, JT McConville (Eds) Informa Press 2007
• Smyth, H. D. C., Evans, R. M., Hickey, A. J., Aerosol Generation from Propellant-driven metered dose inhalers in Inhalation Aerosols, Lung Biology in Health and Disease, Marcel Dekker, Inc., 2nd Edition, 2006.
• Smyth, H.D.C., Pulmonary Excipients in "Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems", Katdare, A. and Chaubal, M. (Eds). Informa Press, New York 2006.
• Smyth, H.D.C., Garmise, R., Cooney, D., Garcia-Contreras, L., Jones, L.D., Hickey, A.J. Medical and Pharmaceutical Aerosols in Aerosols Handbook: Measurement, Dosimetry, and Health Effects, Ruzer, L. & Harley, N.H. (eds), CRC Press. 2005